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1. HTTP CHEMLAB PC MARICOPA EDU PERIODIC PERIODIC HTML ARCHIVE
2. HTTP CHEMLAB PC MARICOPA EDU PERIODIC PERIODIC HTML SOFTWARE

Parent through metabolite to possible toxic outcomes?

HTTP CHEMLAB PC MARICOPA EDU PERIODIC PERIODIC HTML SOFTWARE

Anybody else know of software to take a molecule I am not sure if the softwareįor metal complexes. Program will predict the metabolites based on phase I & II metabolism, Predict") that allows you to input the parent molecule structure and the Software program (cant recall the name, but it was something like I did find some chemical structure figures for borinic acidįrom structure you can sometimes predict toxicity. Metal interactions in biological environments, which may be useful. also has some useful chapters on the basics of New York, Macmillan Publishing Company.Ĭalabrese, E.J. Casarett and Doull's Toxicology, the Basic yielded quite a few interesting links thatĭeficienciesToxicities/Boron_toxicity.htmĪnd some references I also found Boron information in: (using words like boron physicochemical "borinic acid" I have not worked with Boron derivatives before, and as Harold On at 13:57:03, "Jon Monteleone" (monte.at.nz) sent the message.Pharmaceutical n Medical n Biotechnology - Nutraceutical Consultant Try putting in "boron and toxicity and review" and you can get started. I conducted a search on PubMed, using the Boolean feature (link below): On at 13:04:30, "Clerk Maxwell" (clerkmaxwell.at.) sent the message.boronic acid derivatives (the boron has one References on the toxicity of borinic acid derivatives (the boron has I read with interest your comments on metal toxicity. On at 17:08:56, "Ving Lee" () sent the message.Jonathan Monteleone (MS), j.monteleone.at.auckland.ac.nzĭept of Pharmacology & Clinical Pharmacology, School of MedicineĨ5 Park Rd, Private Bag 92019, Auckland, New Zealand Fundamental and Applied Toxicology 9: 730-737. (1987) Metabolism and excretion of galliumĪrsenide and arsenic oxides by hamsters following intratracheal National Academy of Sciences, Washington, D.C. (1977) Medical and Biological Effects of Environmental Pollutants:Īrsenic. (1994) Assessment of exposure toĪrsenic following ingestion of marine organisms by volunteers. I am sure a search of medline will produce many good articles, but hereīuchet JP, Pauwels J, Lauwerys R. The best information onĪDME-PK/PD issues is likely to found in the toxicology literature. Lipophilic the metal can be made (through complexation with organic The PD effects of the metal are mainlyĭependent on what the metal has found to form a complex with, but Where the metal complex will go in the body, and how it will beĪnd eliminated from the body. How the metal may gain access systemically, what the metal will bind to,

Through the body will influence both PK and PD. How these factors change (or do not change) as the metal The kinetics of a metal in the body is related to its valence and On at 10:03:49, "Jonathan Monteleone" (j.nz) sent the message.Can someone provide information on these issues? Thanks a lot. In animals or humans, and the PK/PD interactions between metals and VOCsĪs well. Pharmacodynamics interactions of metals such as lead, mercury, and I am looking for some literatures of studying pharmacokinetic and/or On at 16:26:49, Sheng-Wei Wang (.edu) sent the message.

HTTP CHEMLAB PC MARICOPA EDU PERIODIC PERIODIC HTML ARCHIVE

PharmPK Discussion List Archive - PK2004429.html - 2004 PharmPK Discussion - Pharmacokinetic and pharmacodynamic interactions of metals PharmPK Discussion List Archive Index page